Go to Apple > System Settings

Choose >Sound>Output>Focusrite Thunderbolt

Click on >File Load Snapshot

Load the Snapshot for that suite
Go to >Tempstorage>
Go to Folder
USE THIS Focusrite setup for CMB 4112 A and B
Click Open

Click on Device Settings
Red 4Pre
Clock Source make sure it is internal
Make sure that the FocusRite is synced to Internal