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  1. Content
  2. Bioinformatics Team Home
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  4. Training
  5. SSC Intro to NGS Bioinformatics Course

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Jeffrey E Barrick

Scott Patrick Hunicke-Smith

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May 22, 2012

May 22, 2012

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  • Using the Integrative Genomics Viewer (IGV)
  • Shell Scripting
  • Mapped read data evaluation (SAMtools)
  • Installing Linux tools
  • Identifying mutations in microbial genomes (breseq)

Extras (come early Day 3)

  • Calling variants in diploid genomes
  • Annotating variants

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  • SRA toolkit, UCSC Genome Browser
  • Variant calling with GATK
  • Genome variation in mixed samples (FreeBayes, deepSNV)
  • Identifying structural variants (SVDetect)

Even More Extras

  • Download presentation on Advanced Genome Variant Calling
  • Practical advice - short read re-sequencing data

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  • Differential gene expression analysis
  • Splice variant analysis
    <break>
  • non-coding RNA analysis annotation - unique mapping (shrimp/grep), miRNA’s abundance/editing, other: snoRNA, snRNA, lincRNA, piRNA, tRNA, degradome, etc. etc. (not poly-A; not annotated)
  • Transcriptome assembly & annotation velvet/oases, TrinityRNAseq; BLAST, GOminer, (ELI?)

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  • Resources: tool list, file formats & more
  • Scott's list of linux one-liners
  • Example BWA alignment script
  • Exercises

Misc

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This is the link to the gsaf web site

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General
Content
Integrations
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