The order of administration of these two sets of stimuli will be pseudorandomized so that half of all participants with each PPA variant are administered the first set in their L1, and the other half in their L2. Administration of both sets will occur one week apart. Additionally, three identical tasks (QAB Important event discourse task, procedural discourse task Brushing teeth and Picnic scene) will also be administered in both languages. (grant p.6, updated 20240406)

Update: CONTROLES, lab decision 20250829, Administration of both sets will occur one week apart, but 7-10 days is acceptable.

Task administration by timepoint:          

The tasks are organized in this table by order of administration (first to last). The redcap instruments match this order

Timepoint guide:

There are different timepoints depending on the branch of the study Clinical Trial, Observational Study and Screenings and Basic Evaluations

For

• speechFTLD A: Cookie theft, picnic scene, brushing teeth, 10 min

• SpeechFTLD B: picnic scene, brushing teeth, 6m

• For Clinical Trial and Observational study participants:

The administration instructions can be found the Redcap BACC instruments:

Connected Speech S1 And S3 Span
 Connected Speech S1 And S3 Cat
Connected Speech S2 And S3 Span
Connected Speech S2 and S3 Cat

• For extended screening/evaluación básica/non-R01 Obs participants:

• Se rellena instrumento CS set 1 para los dos idiomas: Connected Speech S1 And S3 Span, Connected Speech S2 And S3 Span

• Luego una vez este dentro de estudio R01 cuando se hace sesión de CS se mueven los datos al instrumento que corresponda y se borran los datos de ese instrumento.

! If order of administration is changed after a CS session please remember to fill out the Redcap instrument adding the order of administration by changing the numbers in the comment boxes of each task and adding the dates (do not do this during the session because it interferes with the audio recording).

• Stimuli

The stimuli can be found here in Box: Connected Speech and SpeechFTLD stimuli

EXCEPTIONS of administration (applicable to all branches of the study (R01 clinical trial, R01 Obs, evaluación básica, etc.,) :

Administration exceptions for Severe Patients

When patients have a more severe difficulties and it's probable that they will not be able to complete all the CS tasks, please priorize the Post-treatment CS tasks.

Administer those in the predetermined order (shown in the scheme above and in the CS Redcap instrument)

After completing the CS Post-tx tasks take a small break and if the patient and if the patient isn't showing any moderate-severe signs of stress, tiredness continue with the administration of the CS tasks following the predetermined order of the battery (shown in the scheme above and in the CS Redcap instrument)

After a CS session please remember to fill out the Redcap instrument marking a variation in the order of the task administration and adding the order of administration by changing the numbers in the comment boxes.

Administration exceptions because of time contraint

Please make sure to plan the sessions ahead so there's enough time to administer the CS battery in complete (45 min moderate patients, 1h severe patients. Please read next page "preparation before CS sessions" to avoid this situation happening when possible.

Please priorize the Post-treatment CS tasks.

Administer those in the predetermined order (shown in the scheme above and in the CS Redcap instrument)

After completing the CS Post-tx tasks take a small break and if there's still time continue with the administration of the CS tasks following the predetermined order of the battery (shown in the scheme above and in the CS Redcap instrument).

After a CS session please remember to fill out the Redcap instrument marking a variation in the order of the task administration and adding the order of administration by changing the numbers in the comment boxes.

This tasks were created by Dr. Miguel Ángel Santos-Santos, each of the questions relate to different cognitive domains, the 2 tasks are balanced in terms of questions (Bridge Video, Kindness Video)

Variability in Administration

• 20250929 R01 meeting decision Video task: Issue 1: Differences in whether clinicians stop participants who give extra information beyond the question. Decision: In the video part of the test, participants should be instructed to answer concretely and directly to each question. Issue 2: Variability in asking/skipping questions: Decision : All questions of the video CS part must be asked, even if the participant already answered within another response.