Orbitrap Elite and Fusion notes

Orbitrap Elite and Fusion notes

  • spray shield recommended for use when not doing nanospray including calibration, to keep instrument clean
  • Elite low flow HESI needle OPTON 53010 for use up to 400 ul/min.  This is stable for cal mix at 3 ul/min while high flow needle needs 5-7 ul/min for stability and goes over 1 ml/min
  • nanospray source can be used to calibrate weekly FT but is not recommended for monthly EMT and other calibrations
  • Fusion negative calibration use lower spray voltage 2-2.5 kV
  • check spray stability for 1000 scans not 100 scans, watch that deviation is not large, under 10% but not jumping around
  • Fusion calibration check ion optics, then go to Diagnostics do Orbitrap transmission, isotope ration, isotope interactions, then go back again to Calibration tab and check ion optics